Ivor Lewis经胸颈部机械吻合术治疗中段食管癌的前瞻性研究

Ivor Lewis stapled cervical esophagogastrostomy via thorax for middle esophageal carcinoma: a prospective cohort study

  • 摘要: 目的:探讨IvorLewis经胸颈部机械吻合术治疗中段食管癌的疗效。
    方法:前瞻性研究2005年3月至2013年3月两家医院收治的303例中段食管癌患者(江苏省如皋市博爱医院107例、江苏省如皋市人民医院196例)的临床资料,按患者入院先后顺序编号分为IvorLewis组(151例),施行IvorLewis径路经胸颈部机械吻合术;Sweet组(152例),施行Sweet径路经胸颈部机械吻合术。比较两组患者术中情况、围手术期并发症、淋巴结清扫和术后随访等情况。采用门诊复查方式随访,随访时间截至2012年12日。计量资料采用成组 t检验,计数资料采用χ2 检验或Fisher确切概率法,等级资料采用Wilcoxon成组秩和检验。采用KaplanMeier法绘制生存曲线,COX比例风险模型分析术后死亡风险。
    结果:IvorLewis组的手术时间和手术切除率分别为(239±21)min和98.68%(149/151),Sweet组分别为(188±30)min和92.76%(141/152),两组比较,差异有统计学意义( t=11.32,χ2 =4.65,11.73,7.97,P <0.05)。
    结论:IvorLewis经胸颈部机械吻合术治疗中段食管癌,手术切除率高、安全性好,术后患者生存获益明显。该术式可以作为治疗颈部无肿大可疑转移淋巴结的中段食管癌的优选手术方法。

     

    Abstract: Objective To investigate the efficacy of the Ivor Lewis cervical stapled esophagogastrostomy via thorax in the treatment of middle esophageal carcinoma.
    Methods The clinical data of 303 patients with middle esophageal carcinoma who were admitted to the Rugao Boai Hospital (107 patients) and the Rugao People′s Hospital (196 patients) from March 2005 to March 2013 were prospectively analyzed. All the patients received Ivor Lewis stapled cervical esophagogastrectomy (Ivor Lewis group, 151 patients) or Sweet stapled cervical esophagogastrostomy (Sweet group, 152 patients) according to the admission order. The intraoperative condition, peri operative complications, lymph node dissection and postoperative follow up of the 2 groups were analyzed. All the patients were followed up via out patient examination till December 2012. The measurement data, enumeration data and the ranked data were analyzed using the independent samples t test, chi square test or Fisher exact pro bability and Wilcoxon rank sum test, respectively. The survival curve was drawn by the Kaplan Meier method, and the postoperative mortality rate was analyzed using the Cox proportional hazard model.
    Results The operation time of the Ivor Lewis group was (239±21)minutes, which was significantly longer than (188±30)minutes of the Sweet group ( t=11.32, P =4.65, 11.73, 7.97, P <0.05).
    Conclusion Ivor Lewis stapled cervical esophagogastrostomy via thorax has advantages of high resection rate, better safety and better quality of life of patients, and it could be an optimized design of the treatment for patients with middle esophageal cancer without intumescent lymph node of neck.

     

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